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29 Σεπ 2021 · Male hypogonadism is a condition in which the body doesn't produce enough testosterone or sperm. Learn about the types, causes, symptoms and complications of this disorder, and how it can affect your reproductive system and masculine characteristics.
Spermatogenesis and folliculogenesis involve cell–cell interactions and gene expression orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). FSH regulates the proliferation and maturation of germ cells independently and in combination with LH.
Primary hypogonadism involves failure of the testes to respond to follicle-stimulating hormone (FSH) and luteinizing hormone (LH). When primary hypogonadism affects testosterone production, testosterone is insufficient to inhibit production of FSH and LH; hence, FSH and LH levels are elevated.
Elevated LH and FSH values indicate primary (testicular) hypogonadism, whereas low or importantly even inappropriately ‘normal’ LH and FSH values may indicate secondary (pituitary–hypothalamic) hypogonadism.
17 Ιαν 2023 · Studies from rodent models suggest that gonadotropin hormones (both LH and FSH) support the process of spermatogenesis by suppressing the proapoptotic signals and thus promoting spermatogenic cell survival. The Sertoli cells themselves mediate parts of spermatogenesis through hormone production.
1 Μαΐ 2023 · The hypothalamus secretes GnRH, which stimulates the anterior pituitary to release FSH and LH. In females, FSH receptors are located in the granulosa cells of the ovaries. In males, FSH receptors are found in the Sertoli cells of the testes.
23 Ιαν 2023 · In boys or children assigned male at birth (AMAB), FSH and LH work together to trigger their testes to begin producing testosterone. This is the hormone responsible for the physical changes of puberty (such as body hair growth and voice deepening) and the production of sperm.
