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29 Σεπ 2021 · Male hypogonadism is a condition in which the body doesn't produce enough testosterone or sperm. Learn about the causes, symptoms and diagnosis of this condition, and how it affects the male reproductive system and other aspects of health.
Primary hypogonadism involves failure of the testes to respond to follicle-stimulating hormone (FSH) and luteinizing hormone (LH). When primary hypogonadism affects testosterone production, testosterone is insufficient to inhibit production of FSH and LH; hence, FSH and LH levels are elevated.
Elevated LH and FSH values indicate primary (testicular) hypogonadism, whereas low or importantly even inappropriately ‘normal’ LH and FSH values may indicate secondary (pituitary–hypothalamic) hypogonadism.
23 Ιαν 2023 · In boys or children assigned male at birth (AMAB), FSH and LH work together to trigger their testes to begin producing testosterone. This is the hormone responsible for the physical changes of puberty (such as body hair growth and voice deepening) and the production of sperm.
24 Ιουν 2024 · Hypogonadism in a male refers to a decrease in one or both of the two major functions of the testes: sperm production or testosterone production. These abnormalities can result from disease of the testes (primary hypogonadism) or disease of the hypothalamus or pituitary (secondary hypogonadism).
It is also known as hypogonadotrophic hypogonadism due to low levels of LH and FSH resulting in decreased testosterone production. Secondary hypogonadism often occurs as part of a wider syndrome of hypopituitarism. Examples of causes can include: pituitary tumours and their treatment.
Diagnosis of hypogonadism. Routine screening for hypogonadism in asymptomatic men is not recommended, except in certain conditions (Supplementary Figure S1). Clinical features of hypogonadism are not limited to sexual symptoms — reduced libido, erectile dysfunction (ED), and loss of waking erections.
