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Gene expression profiling (GEP) of DLBCL resulted in the identification of two major and clinically distinct subtypes that are classified based on cell of origin (COO) and are associated with differences in clinical outcome: GCB and non-GCB, which is further comprised of ABC and primary mediastinal B-cell types. 10,11 DLBCL subtypes have ...
There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse outcomes when treated with standard chemoimmunotherapy.
In this report we evaluated impact of choice of therapy and stem cell transplant (SCT) on the outcome of GBC and ABC subtype determined by immunohistochemistry (IHC) using Hans algorithm. Methods: We reviewed pathology reports DLBCL patients diagnosed from 2009 - 2016.
11 Απρ 2018 · The ABC–GCB predictor score is a quantitative metric used to assign DLBCL cases to the indicated gene-expression subgroups. High values (blue) are on the ABC end of the spectrum, and low...
24 Μαρ 2020 · Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtypes have very different clinical courses, with ABC having a much worse survival prognosis.
News. Watch GBC News Radio News. Burglary suspect appears in court to deny charges. More taxis licence holders fined in last six months than ever before, says transport Ministry. UK's first case of dangerous mpox variant; Director of Public Health says 'low risk' to Gibraltar presently but GHA prepared.
