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24 Μαρ 2020 · Diffuse large B-cell lymphoma (DLBCL) is a heterogenous blood cancer, but can be broadly classified into two main subtypes, germinal center B-cell-like (GCB) and activated B-cell-like (ABC). GCB and ABC subtypes have very different clinical courses, with ABC having a much worse survival prognosis.
Outcomes are shown for historic control patients treated with R-CHOP and study patients treated with R2CHOP based on germinal center B-cell (GCB) versus non-GCB diffuse large B-cell lymphoma (DLBCL) subtype. (A) Progression-free survival in patients treated with R-CHOP for non-GCB versus GCB DLBCL.
11 Απρ 2018 · Gene-expression profiling has identified subgroups of DLBCL (activated B-cell–like [ABC], germinal-center B-cell–like [GCB], and unclassified) according to cell of origin that are associated...
There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse outcomes when treated with standard chemoimmunotherapy.
11 Ιουν 2019 · DLBCL is classified according to the cell of origin (COO) into germinal center B-cell (GCB) or activated B-cell (ABC), while leaving out about 10% of cases unclassified.
1 Ιαν 2004 · Using a cDNA microarray, DLBCL can be divided into prognostically significant subgroups with germinal center B-cell–like (GCB), activated B-cell–like (ABC), or type 3 gene expression profiles. 35,36 The GCB group has a significantly better survival than the ABC group. The type 3 group is heterogeneous and not well defined, but has a poor ...
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