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IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells. In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β. [10] .
22 Αυγ 2022 · Interleukin-14 (IL-14) T cells produce IL-14, and its principal effects are stimulation of activated B cell proliferation and inhibition of immunoglobulin secretion. Interleukin-15 (IL-15) Monocytes, epithelium, and muscles make IL-15. It acts on T cells and activated B cells. It causes the proliferation of both B and T cells.
IL-14 was identified as a high molecular weight B-cell growth factor produced by T cells and some B-cell tumors. The precise nature of this putative cytokine is still uncertain, although it has been implicated in the pathogenesis of autoimmune diseases, SLE, Sjögren syndrome (Chapter 55), and Graves disease or Hashimoto thyroiditis (Chapter 70). 74
Interleukin-14 is defined as a high molecular weight B-cell growth factor produced by T cells and some B-cell tumors, with its precise nature still uncertain. AI generated definition based on: Clinical Immunology (Fourth Edition) , 2013
interleukin-14. Ορισμός. Μία κυτταροκίνη που παράγεται από τα Τ-λεμφοκύτταρα και από τα θυλακοειδή δενδριτικά κύτταρα.
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. Mübeccel Akdis MD, PhD, ... Cezmi A. Akdis MD, in Journal of Allergy and Clinical Immunology, 2016. IL-14. IL-14 was first described as a high-molecular-weight B-cell growth factor.
Interleukins, apart from interferons and chemokines, belong to a group of cytokines (Figure 1 A) showing very complex and broad actions in the human body, interacting with all cells of the immune system and other cells and tissues and creating a network of connections—a cytokine network [31].
