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31 Ιαν 2019 · Melanoma, also referred to as malignant melanoma, is a potentially very serious skin cancer in which there is an uncontrolled growth of melanocytes (pigment cells). Normal melanocytes are found in the basal layer of the epidermis (outer layer of skin). Melanocytes produce a protein called melanin, which protects skin cells by absorbing ...
Malignant melanoma may arise from melanocytes found on the skin or rarely from mucosal surfaces, under the nails and in the meninges. Melanoma may arise from common acquired naevi or from dysplastic naevi. They may also arise from the solar lentigo or atypical lentigo. Most arise de novo. The dermoscopic features are enormously variable.
Malignant blue naevus is a primary melanoma arising within a dermal blue naevus. It is blue-black because of the depth of the pigmentation. Desmoplastic melanoma is a fibrous neurotropic tumour that tends to be diagnosed late and has a poor prognosis. It can arise in lentigo maligna, acrolentiginous melanoma or mucosal melanoma.
Desmoplastic melanoma is a rare form of invasive melanoma, a skin cancer that arises from pigment cells (melanocytes). Desmoplastic melanoma often involves nerve fibres, when it is called neurotropic melanoma. The malignant cells within the dermis are surrounded by fibrous tissue.
Amelanotic melanoma can masquerade as a number of non-melanocytic neoplasms [7]. A key feature is the lack of melanin granules; stains that detect melanin granules include Fontana-Masson stain [3]. Immunohistochemical staining may reveal some residual pigment in amelanotic melanoma and identify the malignant cells as melanocytes.
Acral lentiginous melanoma (ALM) is a rare subtype of melanoma arising on the palms, soles, or under the nails. It is also known as acral melanoma. In early stages, ALM often appears as a dark brown or black macule with variegated colour, and can be nodular and ulcerated in advanced cases. ALM is slow-growing, and can take months to years to ...
Lentigo maligna is a precursor to lentigo maligna melanoma, a potentially serious form of skin cancer. Lentigo maligna is also known as Hutchinson melanotic freckle. Lentigo maligna is an early form of melanoma in which the malignant cells are confined to the tissue of origin, the epidermis, hence it is often reported as ‘in situ’ melanoma.
Melanoma of the nail unit is usually a variant of acral lentiginous melanoma, a malignant melanoma arising from the palms of the hands and soles of the feet. Other rare forms of melanoma that may arise in the nail unit are nodular melanoma or desmoplastic melanoma. Melanoma of the nail unit most often affects the great toe and thumbnail ...
Nodular melanoma is an invasive form of melanoma. Melanoma is a potentially dangerous skin cancer that arises from pigment cells (melanocytes). According to New Zealand Cancer Registry data, 2256 invasive melanomas were diagnosed in 2008, and at least 15% were reported as nodular melanoma. There were 371 deaths from all types of melanoma in ...
The 'ugly duckling' sign: identification of the common characteristics of nevi in an individual as a basis for melanoma screening. Arch Dermatol. 1998;134:103–4. doi: 10.1001/archderm.134.1.103-a. PubMed; Harrington E, Clyne B, Wesseling N, et al. Diagnosing malignant melanoma in ambulatory care: a systematic review of clinical prediction rules.
