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Cerebral edema is a condition of excess of fluid in the brain resulting from either neurological or non-neurological causes. Cerebral edema can result from a variety of mechanisms. These include cellular, vasogenic, interstitial, and osmotic mechanisms.
3 Ιουλ 2023 · The histopathology of cerebral edema may show both the underlying pathology (tumor, infection, anoxic changes) as well as diffuse swelling of either the cell bodies in cytotoxic edema or interstitial spaces.
15 Μαρ 2021 · In this chapter, we discuss the history of cerebral edema and current models of cerebral edema pathophysiology. We discuss the diagnosis of cerebral edema, current methods of treatment, and complications of both edema and of its therapeutics.
10 Δεκ 2020 · Recent research has advanced our understanding of the molecular pathophysiology of cerebral edema, exposing the central role of aquaporins and specific ion channels.
Cerebral edema complicates many brain pathologies causing additional injury often in excess of the original neurological insult. Classic descriptions divide cerebral edema into cytotoxic, vasogenic, interstitial, and osmotic subtypes.
Pathophysiology of cerebral edema at cellular level is complex. Damaged cells swell, injured blood vessels leak and blocked absorption pathways force fluid to enter brain tissues. Cellular and blood vessel damage follows activation of an injury cascade.
This review discusses past models and current knowledge regarding the molecular and cellular pathophysiology of cerebral edema. Keywords: Astrocytes; brain edema; capillaries; cerebrospinal fluid; endothelium.
