Αποτελέσματα Αναζήτησης
Large platelets (3–7 μm) are called macrothrombocytes, whereas platelets reaching the size of erythrocytes or lymphocytes (larger than 7, up to 20 μm) are designated giant platelets [1], [11]. Healthy subjects usually have less than 5% of large platelets [11].
Giant platelet disorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelets cannot stick adequately to injured blood vessel walls, resulting in abnormal bleeding when injured.
21 Νοε 2022 · Our morphometric analyses using flow cytometry and electron microscopy showed that critically-ill patients possess platelets with increased MPV, inner complexity, and increased proportions of giant platelets thus substantiating the role of platelets in COVID-19 cardiovascular complications.
A careful analysis of the platelet size and morphology, by detecting either normal platelets with or without excessive anisocytosis, microplatelets, or large/giant platelets, will contribute to inherited thrombocytopenia diagnosis and gather substantial data when looking for an acquired platelet disorders.
9 Μαρ 2017 · Giant platelet characteristics for macrothrombocytopenia are readily recognized by LM (Zucker-Franklin 2003). This method is therefore suitable for the diagnosis of macrothrombocytopenia-associated platelet disorders and certain storage pool diseases.
14 Νοε 2022 · Structure. Platelets form by the fragmentation of megakaryocytes within the bone marrow. Megakaryocytes duplicate in the marrow without dividing, resulting in the production of giant cells.
