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One death occurred on progesterone, which was attributed to sudden unexplained death in epilepsy. A post hoc analysis of the same RCT showed that the pattern of perimenstrual seizure exacerbation (C1) was a significant predictor of ≥50% reduction in all seizures in patients receiving progesterone vs patients receiving placebo.
Natural progesterone can reduce the frequency of seizures. To date, there have been 5 important studies using natural progesterone as a treatment. Natural progesterone is sold in compound pharmacies in lozenge, suppository, lotion, and pill form (Prometrium).
Progesterone combined with antiepileptic therapy was well tolerated and resulted in a significant reduction of seizure frequency in majority of patients with catamenial epilepsy.
Both estradiol and progesterone/allopregnanolone may have beneficial effects for patients with epilepsy. Individualized hormonal therapy should be considered as adjunctive treatment in patients with epilepsy to improve seizure control as well as quality of life.
The main outcome included the efficacy of progesterone and its derivatives on seizure frequency. Results: Nineteen articles (457 patients) were included; four were randomized controlled trials (two comparing progesterone vs placebo and two comparing norethisterone vs placebo). Progesterone was generally administered during the luteal phase ...
This review highlights a significant deficiency within the evidence base for clinical studies of treatments used in catamenial epilepsy. The included RCTs provided very limited data on the effectiveness of norethisterone and progesterone in catamenial epilepsy with regular menses.
12 Ιουν 2012 · This study provides Class III evidence that cyclic progesterone is ineffective in women with intractable partial epilepsy. Post hoc analysis identified a subset of women with higher levels of perimenstrual seizure exacerbation that were responsive to treatment.
