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4 Δεκ 2019 · The 2019 NICE guideline for the management of multiple pregnancy makes updated recommendations to effect enhanced monitoring in pregnancies at highest risk of antenatal complications and introduces new recommendations to safeguard perinatal outcomes during delivery.
However, vaginal progesterone appears to reduce the risk of preterm birth occurring at early gestational ages and of neonatal morbidity and mortality in twin gestations with a sonographic short cervix (cervical length ≤25 mm and <30 mm).
Objective: The early vaginal progesterone for the prevention of spontaneous preterm birth in twins, a randomized, placebo-controlled, double-blind trial, was designed to test the hypothesis that among women with twin pregnancies, vaginal progesterone at a dose of 600 mg per day from 11 to 14 until 34 weeks' gestation, as compared with placebo ...
1 Νοε 2017 · Women with twin pregnancies should not routinely receive vaginal progesterone because it does not reduce the risk of preterm birth. Vaginal progesterone should be administered to reduce...
In women with a twin pregnancy with long cervix (≥30 mm), evidence from one study showed that vaginal progesterone (600 mg per day) had important harm in terms of spontaneous birth between 24 and <34 weeks when compared with placebo. The quality of evidence was moderate.
1 Δεκ 2023 · Twin gestations are associated with increased risk of pregnancy complications. However, high-quality evidence regarding the management of twin pregnancies is limited, often resulting in inconsistencies in the recommendations of various national and international professional societies.
Trials of 17OHP-C in twin 10, 11 and triplet 12, 13 gestations have indicated that this compound does not prevent preterm birth in multiple pregnancies. Three trials have explored the effects of vaginal progesterone in the prevention of preterm birth in twins.