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8 ώρες πριν · Bis(triphenylphosphine)platinum chloride is a metal phosphine complex with the formula PtCl 2 [P(C 6 H 5) 3] 2.Cis- and trans isomers are known. The cis isomer is a white crystalline powder, while the trans isomer is yellow. [3] Both isomers are square planar about the central platinum atom. The cis isomer is used primarily as a reagent for the synthesis of other platinum compounds.
7 Αυγ 2023 · Peripheral T cell lymphoma (PTCL) is a heterogeneous group of lymphomas accounting for 5% to 15% of non-Hodgkin lymphomas (NHL), in the western world. It is comprised of peripheral (systemic) and cutaneous forms developed from T-cells and natural killer (NK) cells. Clinically, these lymphomas are often aggressive. [1] [2] [3]
Peripheral T cell lymphomas (PTCLs) are a rare type of non-Hodgkin lymphoma (NHL). Lymphoma develops when white blood cells called lymphocytes grow out of control. They move around your body in your blood and your lymphatic system. The lymphatic system is an important part of our immune system .
27 Ιουν 2023 · Peripheral T-cell lymphoma (PTCL) isn’t a single disease. The term refers to a group of aggressive (fast growing) blood cancers that affect your lymphatic system and may spread (metastasize) to other areas of your body. Peripheral T-cell lymphomas are a form of non-Hodgkin lymphoma.
11 Νοε 2024 · Relapsed/refractory peripheral T cell lymphomas (PTCLs) are aggressive tumors with a poor prognosis. Unlike B cell lymphomas, treatment of PTCL has not benefited from advances in immunotherapy.
TP53 mutations are frequent events in certain subtypes of PTCL. Patients with TP53-mutated PTCL experience high relapse rates when treated with curative-intent CHOP-based chemotherapy.
8 Φεβ 2023 · While significant therapeutic gains and improved understanding of disease pathogenesis have been realized for selected PTCL subtypes, the most common PTCL in North America remains “not otherwise specified (NOS)” and is an unmet need.
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