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26 Αυγ 2024 · Simvastatin is a statin drug that lowers cholesterol and triglycerides, and reduces the risk of heart complications. It can cause muscle breakdown, liver damage, and birth defects. Do not take it with grapefruit, alcohol, or certain other medicines.
5 Ιουν 2023 · Patients with contraindications to simvastatin pharmacotherapy include those with active liver disease, including those who have elevated hepatic enzymes, pregnancy, and women who may become pregnant or who are breastfeeding.
As well, patients already stabilized on simvastatin 80mg should be monitored closely for evidence of muscle toxicity; if they need to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin, that patient should be switched to an alternative statin with less potential for the drug-drug ...
Contraindications. Simvastatin is contraindicated with pregnancy, breastfeeding, and liver disease. [16] . Pregnancy must be avoided while on simvastatin due to potentially severe birth defects. Patients cannot breastfeed while on simvastatin due to potentially disrupting the infant's lipid metabolism. [17] .
12 Μαρ 2024 · Simvastatin is a statin drug that lowers cholesterol and triglycerides and reduces the risk of heart disease. It has many contraindications, such as liver problems, pregnancy, breast-feeding, and certain drugs. Learn more about its uses, dosage, and precautions.
Indications and Usage for Simvastatin. Simvastatin tablets USP are indicated: (1)
Do not use more than 20 mg per day of simvastatin together with amiodarone (Cordarone®), amlodipine (Norvasc®), lomitapide (Juxtapid™), or ranolazine (Ranexa®). When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems.
