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  1. 1 Ιουλ 2014 · The COP1/SPA complex of Arabidopsis is a well-characterized key negative regulator that actively suppresses the light signaling cascade in dark-grown plants by ubiquitinating transcription factors which mediate the various light responses.

  2. 16 Ιουν 2021 · Here the authors show that the SPA1 kinase regulates distinct thermomorphogenic responses according to tissue type by interactions with PIF4 and HY5 in shoots and roots, respectively.

  3. 23 Μαρ 2021 · Discovered originally in Arabidopsis thaliana, COP1 acts in a complex with SPA proteins as a central repressor of light-mediated responses in plants. By ubiquitinating and promoting the degradation of several substrates, COP1/SPA regulates many aspects of plant growth, development and metabolism.

  4. 16 Απρ 1999 · An Arabidopsis mutant, spa1, identified in a phyA suppressor screen is hypersensitive only to light signals perceived by phyA (7). Analyses suggest that SPA1 encodes a negatively acting factor that functions at an early step in phyA-specific signal transduction.

  5. 15 Αυγ 2006 · Here, we demonstrate that SPA proteins are, moreover, essential for photoperiodic flowering. Mutations in SPA1 cause phyA-independent early flowering under short day (SD) but not long day (LD) conditions, and this phenotype is enhanced by additional loss of SPA3 and SPA4 function.

  6. 17 Ιουλ 2003 · Suppressor of phyA-105 (SPA1) is a phytochrome A-specific signaling intermediate that acts as a light-dependent repressor of photomorphogenesis in Arabidopsis seedlings. SPA1 is part of a small gene...

  7. 1 Νοε 2003 · Here we report that COP1 acts as part of a large protein complex and interacts with SPA1 in a light-dependent manner. We further demonstrate the E3 ubiquitin ligase activity of COP1 on HY5 in vitro and the alteration of that activity by SPA1.

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