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In cardiology, T wave alternans (TWA) is a periodic beat-to-beat variation in the amplitude or shape of the T wave in an electrocardiogram (ECG or EKG). TWA was first described in 1908. At that time, only large variations ("macroscopic" TWA) could be detected.
25 Ιουλ 2022 · T-wave alternans (TWA) refers to periodic beat-to-beat variability in the timing, shape, and/or amplitude of T-waves on the surface electrocardiogram (ECG) [1,2]. TWA therefore reflects sudden changes in temporal heterogeneity in ventricular repolarization, which is an important mechanism underlying reentrant arrhythmias [3,4].
Non-invasive measurement of beat-to-beat alternation of the electrocardiographic T-wave, referred to as T-wave alternans (TWA), is an important marker of risk for sudden cardiac death (SCD). Is this relationship a mere association or is TWA mechanistically linked to SCD?
A 46 year old African American woman with a history of hypertension and seizure disorder was hospitalised for seizures and aspiration pneumonia. On the second hospital day she suddenly became aphasic with loss of power in her left upper and lower extremities. Her ECG revealed sinus rhythm, prolongation of the QT …
28 Νοε 2010 · T-wave alternans, a manifestation of repolarization alternans at the cellular level, is associated with lethal cardiac arrhythmias and sudden cardiac death.
T-wave alternans, an integral component of congenital long QT syndrome, is a phenomenon of beat-to-beat variability in T-wave amplitude, morphology, and sometimes polarity that can trigger life-threatening ventricular arrhythmias.
We review the contemporary understanding of the pathophysiology of repolarization alternans and present a perspective on the use of T-wave alternans (TWA) as a risk stratification marker of malignant ventricular arrhythmias.
