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Ionized (or charged) drugs are not absorbed as efficiently as un-ionized drugs are. Practically speaking, this means that if taken orally, a drug that is a weak acid will be absorbed primarily in the acidic environment; whereas, a drug that is a weak base will be absorbed in the alkaline environment small intestines.
- Drug Metabolism
The primary objective of drug metabolism is to facilitate a...
- Drug Distribution
The process of transferring a drug from the bloodstream to...
- Drug Excretion
The kidney is the principal drug-excreting organ. The three...
- Enzymes
Cyclooxygenase (COX) inhibitors are non-steroidal...
- Autonomic Pharmacology
Autonomic pharmacology is the study of how drugs interact...
- The Parasympathetic Nervous System
Drugs affecting synthesis, storage or release of...
- Drug Metabolism
15 Ιαν 2020 · We showed that weak acids have a broad spectrum of activity against a wide range of bacteria, including antibiotic resistant bacteria. Further, we showed that a weak acid drug, NAC, can kill bacteria without being toxic to human cells, if its pH is maintained close to its pKa.
Most drugs are weak organic acids or bases, existing in un-ionized and ionized forms in an aqueous environment. The un-ionized form is usually lipid soluble (lipophilic) and diffuses readily across cell membranes.
1 Δεκ 2020 · We showed that weak acids have a broad spectrum of activity against a wide range of bacteria, including antibiotic resistant bacteria. Further, we showed that a weak acid drug, NAC, can kill bacteria without being toxic to human cells, if its pH is maintained close to its pKa.
29 Ιουν 2015 · A weak acid is more WATER-soluble in an alkaline solution. A weak base is more WATER-soluble in an acidic solution. The determined exam candidate looking for detailed published literature on this subject will usually find a satisfactory depth in any major pharmacology textbook. Goodman and Gilman dedicate about half a page to the subject.
6 Ιουλ 2017 · Two weak acid drugs, N-acetyl-L-cysteine (NAC) and acetic acid are emerging as interesting potential therapeutics to treat biofilm-based infections.
15 Ιαν 2020 · We showed that weak acids have a broad spectrum of activity against a wide range of bacteria, including antibiotic resistant bacteria. Further, we showed that a weak acid drug, NAC, can kill bacteria without being toxic to human cells, if its pH is maintained close to its pKa.
